Tobacco Cessation within TB programmes: A ‘real world’ solution for countries with dual burden of disease

Project Progress :

54 % progress so far

Started Date:November 01 2016 Estimated Complete Date:December 30 2019


Tobacco Cessation within TB programmes: A ‘real world’ solution for countries with dual burden of disease

Categories :

Randomized Control Trial (RCT)

Running

This is a double blind multi country randomised control trial (RCT) being implemented to test the integration of an expensive tobacco cessation strateies of proven efficacy into TB control program. The trial will be implemented in multiple districts in central, eastern and far western.   

Objectives

• To determine whether cytisine is effective and cost-effective, when added to behavioural support (BS), for tobacco cessation compared to BS alone on tobacco cessation in TB patients who smoke tobacco on a daily basis.

Other objectives are:

  1. To assess the effectiveness and cost-effectiveness of tobacco cessation strategies (cytisine when added to BS) in improving the clinical outcomes of TB patients who smoke tobacco on a daily basis
  2. To assess any differences in the effectiveness of these strategies by the form of tobacco used (tobacco smoking only versus a combination of smoking and smokeless tobacco)
  3. To assess any differences in the effect across different TB severity groups, high and low socio-economic status (SES), gender and age sub-groups
  4. To first translate for use in the target population and then assess psychometric properties (validity and reliability) of the Mood and Physical Symptoms Scale (MPSS) for the assessment of withdrawal symptoms, and the Strength of Urges to Smoke (SUTS) for the assessment of nicotine  dependency
  5. To assess adverse effects of these strategies in the target population
  6. To assess all relevant components of the design and delivery of the smoking cessation programme